Intensive Care Foundation funded research projects

Click onto the research project titles below for more information about each intensive care research project. Grants are listed by year awarded.

Year Research Projects
2010

A randomised controlled study comparing the effect of two different anticoagulation regimens on filter life during Continuous Renal Replacement Therapy (CRRT) - The Heparin Citrate (THC) Study.

Chief Investigator: Dr David Gattas

2010

Development of a new hyperosmolar solution for use in Neurotrauma.

Chief Investigator: A/Prof Hayden White

2010

MRI determination of renal blood flow during Acute Renal Failure in critically ill patients.

Chief Investigator: Prof Ronaldo Bellomo

2010

Pilot RCT of Continuous Beta-lactam infusion compared with intermittent dosing in critically ill patients.

Chief Investigator: Prof Jeffrey Lipman

2010

PCT guided antibiotic decision makling in ICU.

Chief Investigator: A/Prof Yahya Shehabi

2010

The efficacy, cost effectiveness, and environmental impact of Selective Decontamination of the Digestive tract in critically ill patients treated in the Intensive Care Unit (The SuDDICU study).

Chief Investigator: Dr Ian Seppelt

2010

Patient comfort and safety practices in ICU.

Chief Investigator: Prof D Elliott

2009 Compliance with Processes of Care in the Intensive Care Unit. Chief Investigator: Dr Tony Burrell
2009 Economic Evaluation of Resuscitation in Sepsis. Chief Investigator: Professor Rinaldo Bellomo
2009 The RELEVENT Study. Chief Investigator: Professor D J (Jamie) Cooper
2009 Mapping ICU Liaison Nurse Services in Australia. Chief Investigator: Suzanne Eliott
2009

An Audit of the Time and Costs involved in the Ethical and Governance Review Process of a Multi-Centre Clinical Trial in Australia and New Zealand – TAME Study (Time and Money Evaluation). Chief Investigator: Belinda Howe

2009 Impact of the Intensive Care Discharge Process on Patient Outcomes. Chief Investigator: A/Prof John Santamaria
2009 The effect of varying arterial carbon dioxide concentrations (PaCo2) within the normocapnic range on brain tissue oxygenation and microdialysis markers of cell injury in severe traumatic brain injury. Chief Investigator: Professor David James Cooper
2009 The ANZICS Clinical Trials Group Point Prevalence Program. Chief Investigator: Dr Ian Seppelt
2009 Haemodynamic Effects of Paracetamol. Chief Investigator: Susan Kelly
2008 Bicarbonate in cardiac surgery. Chief Investigator: Prof Rinaldo Bellomo In progress
2008 Heparin in severe sepsis: IL-6 as a marker of efficiency. Chief Investigator: Dr Alistair Nichol Completed
2008 Optimal ventilation (PHARLAP) in acute lung injury. Chief Investigator: Prof D. James (Jamie) Cooper In progress
2008 Nutritional therapy of severe acute pancreatitis. Chief Investigator: Dr Andrew Davies In progress
2008 Reducing CSF sampling frequency to minimise ventriculitis. Chief Investigator: A/Prof Gavin Leslie In progress
2008 Western Australia Outcome Obtained by Linkage - A study of feasibility. Chief Investigator: Clin A/Prof Steve Webb Commencing
2007 Aminophylline in Severe Bronchiolitis. Chief Investigator: Dr Rob Henning  In progress
2007

The Australasian Resuscitation is Sepsis Evaluation (ARISE).  Chief Investigator Peake, S Completed

2007

Heparin in Severe Sepsis.  Chief Investigator: Robertson, MIn progress

2007    

Hypothermia in Traumatic Brain Injury in Children (HiTBIC).  Chief Investigator: Beca, J In progress

2007    

New Insights into Brain Injury in Infants Undergoing Surgery for Congenital Heart Disease.  Chief Investigator: Sherkerdemian, L In progress

2007    

Probiotics & Enteral Nutrition Reducing Diarrhoea in ICU.  Chief Investigator: Leanne, J In progress

2006    

A Routine Daily Interruption to Sedation (AROUSE).  Chief Investigator: Weisbrodt, L Completed

2006    

A Trial of Nebulised Heparin in Acute Lung Injury.  Chief Investigator: Dixon, B Completed

2006    

Low-dose angiotesin II in experimental early and sustained septic renal dysfunction (Angiotensin II in experimental septic acute renal failure).  Chief Investigator: Bellomo, R Completed

2006    

RADICAL  Chief Investigator: Iredell, J Completed

2006    

Ventilation and Weaning Practices in Australia & New Zealand. Chief Investigator: Rose, L Completed

2005    

Bispectral Index-Guided Sedation as Compared to Standard Practice of Sedation in PICU: A Prospective, Randomised, Single Blind Experimental Study.  Chief Investigator: Ramelet, A

2005    

Early Nasojejunal Tube to meet Energy Requirements in Intensive Care study (The ENTERIC study) Chief Investigator: Davies, A In progress

2005    

Lung Injury Associated with Cardiac Surgery. Chief Investigator: Dixon, B

2005    

Preoperative Intravenous N-Acetylcsteine for the Prevention of Renal Failure in Patients with Renal Impairment Undergoing Cardiac Surgery Chief Investigator: Shehabi, Y Completed

2005    

Review of Retrieval Services for the Critically Ill.  Chief Investigator: Flabouris, A  Current

2005    

The effect of N-Acetylcysteine on renal function after cardiopulmonary bypass guidelines for nutritional support in the intensive care.  Chief Investigator: Bellomo, R  Completed and Published

2004    

A Prospective Study of Non-Invasive Ventilation in Patients with Acute Respiratory Failure in Australia. Chief Investigator: Bersten, A

2004    

Effectiveness of the Medical Emergency Team: a randomised clinical trial.  Chief Investigator: Hilman, K  Completed and Published

2004    

Kidney and Brain bioenergetics in Severe Sepsis.  Chief Investigator: Bellomo, R

2004    

Profiles of Gradated Compression Stockings in Intensive Care.  Chief Investigator: Limpus, A

2004    

Scheduled Antibiotic Cycling in Intensive Care.  Chief Investigator: Iredell, J

2004

2003

Developing and Evaluating Evidence-Based Guidelines for Nutritional Support in the Intensive Care Unit.  Chief Investigator: Doig, G  Completed

2004

2003

Early Decompressive Craniectomy in Brain Injury (DECRA) Chief Investigator: Cooper, DJ In progress

2003    

Relationship Between Tissue Hypoxia and Apoptosis.  Chief Investigator: Venkatesh, B

2002     Therapeutic Strategies in Severe Smoke Inhalation.  Chief Investigator: Fraser, J
2001    

Tissue Oxygenation During Endotoxaemia.  Chief Investigator: Venkatesh, B

2000    

Vasoactive Drugs and Regional Circulations.  Chief Investigator: Bellomo, R

1999    

Hypertonic Saline in Head Injured Trauma Patients - a prospective controlled clinical trial.  Chief Investigator: Cooper, DJ  Completed and Published

1998    

Investigate Haemodynamic and Respiratory Effects of Pressure-Support Ventilation. Chief Investigator: Raper, R

1998    

Using Endotoxin Tolerance to Treat Septic Shock.  Chief Investigator: Presneill, J

1997

1996

The effects of high volume mechanical ventilation on systemic inflammation in an animal model of pneumonia. Chief Investigator: Bernsten, AD
1996    

Combination Anti-cytokine Therapy in Septic Shock.  Chief Investigator: Peake, S

1995    

Nitric Oxide in Acute Brain Injury.  Chief Investigator: Finfer, S

1994

1993

Rapid Detection of Gram Negative Sepicaemia by PCR.  Chief Investigator: Corke, C

1994    

Role of Endothelin-1 in the Hypoxic Pulmonary Vascular Response to Acute Respiratory Failure.  Chief Investigator: Watkins, N

1992    

Use of digoxin-specific Fab fragments to remove digoxin-like immunoreactive substance (DLIS) in a rat model of hepatic encephalopathy. Is DLIS of pathological significance?  Chief Investigator: Hawker, F  Completed and Published

1989    

Selenium deficiency and oxygen oxicity in the rat  Chief Investigator: Hawker, F  Completed and Published

1988    

Developing an Innovative Cardiac Arrhythmia Teaching Tool.  Chief Investigator: Harding, J

1988    

Investigate medication system failures in ICU.  Chief Investigator: McWilliam, D

 

Funded       Research Project
2008           Funding for 2008 research projects will be announced on 27 October 2007
2007           Absorption and Upper Gastrointestinal Motility in Critical Illness
                  Chief Investigator: Chapman, M
2007           Aminophylline in Severe Bronchiolitis
                  Chief Investigator: Wilkins, B
                  Commencing
2007           The Australasian Resuscitation is Sepsis Evaluation (ARISE)
                  Chief Investigator: Peake, S
                  Completed
2007           Heparin in Severe Sepsis
                  Chief Investigator: Robertson, M
                  Commencing
2007           Hypothermia in Traumatic Brain Injury in Children (HiTBIC)
                  Chief Investigator: Beca, J
                  In progress
2007           New Insights into Brain Injury in Infants Undergoing Surgery for Congenital Heart Disease
                  Chief Investigator: Sherkerdemian, L
2007           Probiotics & Enteral Nutrition Reducing Diarrhoea in ICU
Chief Investigator: Leanne, J
2006           A Routine Daily Interruption to Sedation (AROUSE)
                  Chief Investigator: Weisbrodt, L
In progress
2006           A Trial of Nebulised Heparin in Acute Lung Injury
                  Chief Investigator: Dixon, B
2006           Low-dose angiotesin II in experimental early and sustained septic renal dysfunction (Angiotensin II in experimental septic acute renal failure)
                  Chief Investigator: Bellomo, R
2006           RADICAL
                  Chief Investigator: Iredell, J
2006           Ventilation and Weaning Practices in Australia & New Zealand
Chief Investigator: Rose, L
2005           Bispectral Index-Guided Sedation as Compared to Standard Practice of Sedation in PICU: A Prospective, Randomised, Single Blind Experimental Study
                  Chief Investigator: Ramelet, A
2005           Early Nasojejunal Tube to meet Energy Requirements in Intensive Care study (The ENTERIC study)
                  Chief Investigator: Davies, A
                  Current
2005           Lung Injury Associated with Cardiac Surgery
                  Chief Investigator: Dixon, B
2005           Preoperative Intravenous N-Acetylcsteine for the Prevention of Renal Failure in Patients with Renal Impairment Undergoing Cardiac Surgery Completed
                  Chief Investigator: Shehabi, Y
2005           Review of Retrieval Services for the Critically Ill
                  Chief Investigator: Flabouris, A
                  Current
2005           The effect of N-Acetylcysteine on renal function after cardiopulmonary bypass guidelines for nutritional support in the intensive care
                  Chief Investigator: Bellomo, R
                  Completed and Published
2004           A Prospective Study of Non-Invasive Ventilation in Patients with Acute Respiratory Failure in Australia
                  Chief Investigator: Bersten, A
2004           Effectiveness of the Medical Emergency Team: a randomised clinical trial
                  Chief Investigator: Hilman, K
                  Completed and Published
2004           Kidney and Brain bioenergetics in Severe Sepsis
                  Chief Investigator: Bellomo, R
2004           Profiles of Gradated Compression Stockings in Intensive Care
                  Chief Investigator: Limpus, A
2004           Scheduled Antibiotic Cycling in Intensive Care
                  Chief Investigator: Iredell, J
2003,2004   Developing and Evaluating Evidence-Based Guidelines for Nutritional Support in the Intensive Care Unit
                  Chief Investigator: Doig, G
                  Completed
2003, 2004  Early Decompressive Craniectomy in Brain Injury (DECRA)
                  Chief Investigator: Cooper, DJ
                  Current
2003           Relationship Between Tissue Hypoxia and Apoptosis
                  Chief Investigator: Venkatesh, B
2002           Therapeutic Strategies in Severe Smoke Inhalation
                  Chief Investigator: Fraser, J
2001           Tissue oxygenation during endotoxaemia
                  Chief Investigator: Venkatesh, B
2000           Vasoactive Drugs and Regional Circulations
                  Chief Investigator: Bellomo, R
1999           Hypertonic Saline in Head Injured Trauma Patients - a prospective controlled clinical trial
                  Chief Investigator: Cooper, DJ
                  Completed and Published
1998           Investigate Haemodynamic and Respiratory effects of pressure-support ventilation
Chief Investigator: Raper, R
1998           Using Endotoxin Tolerance to Treat Septic Shock
                  Chief Investigator: Presneill, J
1997, 1996  The effects of high volume mechanical ventilation on systemic inflammation in an animal model of pneumonia
                  Chief Investigator: Bernsten, AD
1996           Combination Anti-cytokine Therapy in Septic Shock
                  Chief Investigator: Peake, S
1995           Nitric Oxide in Acute Brain Injury
                  Chief Investigator: Finfer, S
1994, 1993  Rapid Detection of Gram Negative Sepicaemia by PCR
                  Chief Investigator: Corke, C
1994           Role of Endothelin-1 in the Hypoxic Pulmonary Vascular Response to Acute Respiratory Failure
                  Chief Investigator: Watkins, N
1992           Use of digoxin-specific Fab fragments to remove digoxin-like immunoreactive substance (DLIS) in a rat model of hepatic encephalopathy. Is DLIS of pathological significance?
                  Chief Investigator: Hawker, F
                  Completed and Published
1989           Selenium deficiency and oxygen oxicity in the rat
                  Chief Investigator: Hawker, F
                  Completed and Published
1988           Developing an Innovative Cardiac Arrhythmia Teaching Tool
                  Chief Investigator: Harding, J
1988           Investigate medication system failures in ICU
                  Chief Investigator: McWilliam, D
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